Waldenstrom macroglobulinemia is a chronic, slow-growing lymphoproliferative disorder. It usually affects older adults and is primarily found in the bone marrow . Waldenström macroglobulinemia (WM) is a distinct clinicopathologic entity demonstrating lymphoplasmacytic lymphoma (LPL) in the bone. Waldenström macroglobulinemia is often an indolent disorder, and many patients are candidates for observation with careful monitoring.

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Older diagnosis and treatments resulted in published reports of median survival of approximately 5 years from time of diagnosis. But on occasion, the disease can be fatal, as it was to the French president Georges Pompidouwho died in office in Differential diagnosis Table 3 is important for the exclusion of neoplasms potentially secreting monoclonal IgM and which can also present lymphocytes with lymphoplasmocytoid differentiation in the bone marrow.

Waldenström’s macroglobulinemia – a review

Recently, autologous bone marrow transplantation has been added to the available treatment options. In patients with short-term remission or resistance to initial treatment, therapy with a drug of different pharmacological class as monotherapy or combined is recommended. However, the serum viscosity is not always proportional to the concentration of IgM and its relationship to symptoms is not linear. Although believed to be a sporadic disease, studies have shown increased susceptibility within families, indicating a genetic component.

Waldenström’s macroglobulinemia

Other factors may contribute to its aggravation, such as gastrointestinal bleeding, hyperhemolysis, and hyperviscosity itself, which may cause a decrease in the erythropoietin synthesis. International prognostic scoring system for Waldenstrom macroglobulinemia. The concentration of sCD27 and assessment of the amount of monoclonal free light chains have been presented as potential biomarkers for laboratory monitoring of therapy.


A bone marrow biopsy provides a sample of bone marrow, usually from the back of the pelvis bone.

Nodular, interstitial, diffuse or mix of all three. J Dtsch Dermatol Ges. Increased plasma viscosity as a reason for inappropriate erythropoietin formation. IgA and IgG hypogammaglobulinemia in Waldenstrom’s macroglobulinemia. Most lymphomas have a similar immunophenotype to MALT lymphoma, others have a similar immunophenotype to splenic marginal zone lymphomas. The use of bortezomib proteasome inhibitor has proven promising, as well as alemtuzumab anti-CD52 monoclonal antibody datalidomida, enzastaurin protein kinase C inhibitoreverolimus inhibitor of mammalian target of rapamycin – mTOR and perifosine Akt inhibitor.

WM is a rare disorder, with fewer than 1, cases occurring in the United States annually.

Waldenström’s macroglobulinemia – Wikipedia

Vijay A, Gertz M. LPLs are rare and indolent cancers of mature B-lymphocytes, which predominantly involve the bone marrow and, less commonly, the spleen, lymph nodes, peripheral blood and other organs.

B-cell neoplasms with homogeneous cold-reacting walvenstrom cold agglutinins. It is therefore believed that epigenetic modifications play a crucial role in the disease. The infiltration of malignant cells in the central nervous enfermead is responsible for a rare neurological disorder called Bing-Neel syndrome. The large size of the monoclonal IgM molecule and its high concentration contribute to increased blood viscosity and vascular resistance, compromising the blood flow to oxygenate tissues.

Internal Medicine 5th ed. Lia; Advani, Ranjana H. Should treatment be started it should address both the paraprotein level and the lymphocytic B-cells.

Monoclonal IgM can also connect nonspecifically to multiple antigens of the peripheral nerves, triggering axonal impairment. WM is an “indolent lymphoma” i. In patients at low risk, the average survival time is 12 years, and treatment should involve low toxicity, preserving quality of life. Monoclonal IgM can wwldenstrom platelet dysfunction by binding to IIIa and Ib glycoproteins on the surface of xe or due to nonspecific interactions with platelets.


Thus, in most cases, the neoplastic B cells present somatic hyper-mutation in the genes coding the hypervariable regions of the immunoglobulin heavy chains V H genes. Rituximab is an IgG1 anti-CD20 monoclonal antibody.

Its etiology is unknown, but several studies suggest a possible causal relationship with autoimmune diseases, exposure to environmental factors and chronic antigenic stimulation, such as infection with the hepatitis C virus HCV. Nature Clinical Practice Neurology. Walddenstrom genomic hybridization identified the following chromosomal abnormalities: Serum protein electrophoresis results indicate evidence of a monoclonal spike but cannot establish the spike as IgM.

The most frequent neurological disorder is a demyelinating distal symmetrical sensorimotor peripheral neuropathy, which manifests itself slowly and progressively, causing paresthesia and asthenia. Pruzanski W, Shumak KH. Patients experience pain, the sensation of “electric shocks” and thermal sensitivity in the lower limbs. LPL may eventually evolve into a more aggressive wwldenstrom of lymphoma such as as diffuse large B-cell lymphoma.